Identification of rat susceptibility loci for adjuvant-oil-induced arthritis

Identification of rat susceptibility loci for adjuvant-oil-induced arthritis.

One intradermal injection of incomplete Freund's adjuvant-oil induces a T cell-mediated inflammatory joint disease in DA rats. Susceptibility genes for oil-induced arthritis (OIA) are located both within and outside the major histocompatibility complex (MHC, Oia1). We have searched for disease-linked non-MHC loci in an F2 intercross between DA rats and MHC-identical but arthritis-resistant LEW....

Identification and isolation of dominant susceptibility loci for pristane-induced arthritis.

Rheumatoid arthritis is a chronic inflammatory autoimmune disorder, controlled by multiple genes as well as environmental factors. With animal models, like the pristane-induced arthritis (PIA) in rats, it is possible to reduce the environmental effects and the genetic heterogeneity to identify chromosomal regions harboring genes responsible for the arthritis development. The PIA model has prove...

Identified in the Rat Homology with Susceptibility Loci Previously Collagen-Induced Arthritis in Mice: Striking Identification of Genes Controlling

Identification of hypertension susceptibility loci on rat chromosome 12.

Previous studies have identified multiple blood pressure and renal disease quantitative trait loci located on rat chromosome 12. In the present study, we narrowed blood pressure loci using a series of overlapping Dahl salt-sensitive/Mcwi (SS)-12 Brown Norway (BN) congenic lines. We found that transferring 6.1 Mb of SS chromosome 12 (13.4-19.5 Mb) onto the consomic SS-12BN background significant...

Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBAy1j mice (rheumatoidygenome scanycollagen-induced arthritis)

One approach to understanding common human diseases is to determine the genetic defects responsible for similar diseases in animal models and place those defective genes in their corresponding biochemical pathways. Our laboratory is working with an animal model for human rheumatoid arthritis called collagen-induced arthritis (CIA). We are particularly interested in determining the location of d...